Nicholas: Living Well With HIV
Living Well With HIV
Buch
- tredition GmbH, 05/2024
- Einband: Kartoniert / Broschiert, Paperback
- Sprache: Englisch
- ISBN-13: 9783384219756
- Bestellnummer: 11857210
- Umfang: 128 Seiten
- Gewicht: 229 g
- Maße: 234 x 155 mm
- Stärke: 10 mm
- Erscheinungstermin: 6.5.2024
Achtung: Artikel ist nicht in deutscher Sprache!
Klappentext
An estimated. two-thirds of the 36.7 million people infected with. the Human immunodeficiency. virus (HIV), resideon the African. continent 1. Once infection. has occurred, HIV destroys. the hosts CD4+ immune. cells, leading to
acquired. immunodeficiency syndrome (AIDS) 2. .HIV/AIDS is wide. spread throughout. Sub-Saharan Africa and
exacerbates various. socioeconomic issues 3. South Africa has. some of the highest prevalence. of HIV/AIDS. in the
world, with an. estimated 7 million people. living with HIV 4. .An estimated 115 000.HIV-related deaths occurred in
South Africa in 2018, .emphasizing the. need for HIV research. in Sub-Saharan. countries 4.
The HIV-1 virus. consists of two copies. of non-covalently. linked, positive. sense, single-stranded. RNA molecules 5.
This is enclosed. by a p24 viral. protein. conical capsid, situated. within a. viral envelope. .The viral envelope is
derived from the. host cell membrane and. contains viral. glycoproteins; such. as gp120.and gp41, which. are
imbedded. in the viral. envelope 2, 6,7. .Once HIV-1 exposure. occurs, .the virus migrates. to CD4+ immune. cells. This
occurs. due to the. affinity of the HIV-1 viral. envelope. gp120 / gp41 complex. for CD4 antigen. receptors on the
surface of host. CD4+ immune cells 2, 6. Once. the gp120 subunit. of the viral envelope. interacts with a CD. antigen
receptor, co-receptor binding. takes place 2, 7. The co-receptor. binding results in conformation. changes in the HIV-
1 envelope, .leading to the exposure. of the gp41 hydrophobic. domain, allowing. fusion of the. envelope with. the
cellular. membrane and the. subsequent delivery. of the viral core. into the cytoplasm 2. The. uncoating of the. viral
core exposes. Reverse transcriptase, a HIV. enzyme, to deoxynucleotide. triphosphates (dNTP s), resulting in
reverse transcription. and proviral DNA synthesis 2. After reverse. transcription is completed, .the formation. of a
complex, consisting of. viral and cellular components is. formed, known as the viral pre-integration. complex. This is
transported to the. cell s nucleus where the. HIV-1 enzyme, Integrase, catalyses. the integration of the viral. genome
with the human. DNA 2, 7. This maintains the. viral DNA. in the infected host cell and allows. transcription, thus the
cell can express viral. mRNA and viral RNA. Once. transcription is initiated, the necessary viral. constituents move
to the inside of the plasma. membrane and assemble to form an. immature HIV-1 virus 2. The newly. formed
immature virus buds. off from the cell and releases. protease to break down large. HIV-1 protein chains. .These
broken down HIV protein. chains, combine to form. a mature HIV-1 virus 2.
The viral life. cycle, discussed above (shown in Figure 1.1), can be. subdivided into seven. distinct stages, namely
binding; fusion; reverse. transcription; integration; replication; .virus assembly / production; and. budding. The HIV-1
lifecyclexpresents various. potential opportunities for. therapeutic intervention. and six distinctclasses of
antiretrovirals (ARVs) havexbeen developed 2.
Anmerkungen:
Bitte beachten Sie, dass auch wir der Preisbindung unterliegen und kurzfristige Preiserhöhungen oder -senkungen an Sie weitergeben müssen.
Mehr von Nicholas
![Nicholas: Beyond Earth: The Search for Life's Fingerprint in Organic Matter, Buch](https://media1.jpc.de/image/h90/front/0/9783384258243.jpg)
Nicholas
Beyond Earth: The Search for Life's Fingerprint in Organic Matter
Buch
EUR 30,89*
![Nicholas: Researching the Relationship Between Time and Space: A Compilation of Quotations, Buch](https://media1.jpc.de/image/h90/front/0/9783384255884.jpg)
Nicholas
Researching the Relationship Between Time and Space: A Compilation of Quotations
Buch
EUR 28,10*
![Nicholas: Beyond Michaelis-Menten: Modernizing the Equation for Enzyme Kinetics, Buch](https://media1.jpc.de/image/h90/front/0/9783384253057.jpg)
Nicholas
Beyond Michaelis-Menten: Modernizing the Equation for Enzyme Kinetics
Buch
EUR 29,10*
![Nicholas: Taming the Flame: Advancing Clean Combustion Technologies, Buch](https://media1.jpc.de/image/h90/front/0/9783384250506.jpg)
Nicholas
Taming the Flame: Advancing Clean Combustion Technologies
Buch
EUR 28,75*
![Nicholas: The Fight Against HIV Continues: High Prevalence Persists Despite Progress, Buch](https://media1.jpc.de/image/h90/front/0/9783384245045.jpg)
Nicholas
The Fight Against HIV Continues: High Prevalence Persists Despite Progress
Buch
EUR 27,39*
![Nicholas: Living Well With HIV, Buch](https://media1.jpc.de/image/w468/front/0/9783384219756.jpg)
Nicholas
Living Well With HIV
EUR 26,59*