Helene Andersson: Lab-on-Chips for Cellomics, Gebunden

Beschreibung

The convergence of life sciences and micro / nanotechnologies is one of the fastest growing modern R and D areas with an enormous potential societal impact. Microfluidics or Lab-on-Chip (LOC) devices, also dubbed BioMEMS, are a fascinating example of this combination of two scientific areas. This book, which is the first volume entirely dedicated to microfabricated cell-based systems, will provide readers with a quick introduction to the field as well as with a variety of specific examples of such Lab-on-Chip systems for cellomics applications. It will give investigators inspiration for innovative research topics, whereas end users will be surprised about the wide variety of new and exciting applications.

Inhaltsangabe

1: Microfluidic devices for cellomics; H. Andersson and A. van den Berg 2: Pretreatment of biological samples for microchip analysis; J. Ferrance, J. Landers 3: Liposomes as cellular model systems; L Locascio, W. Vreeland, A. Jahn, and M. Gaitan 4: A versatile chip-based tool for the controlled manipulation of microparticles in biology using high frequency electromagnetic fields; C. Duschl, P. Geggier, M. Jäger, M. Stelzle, T. Müller, T. Schnelle, G. Fuhr 5: Microelectroporation in cellomics; B. Rubinsky 6: Patch clamp microsystems; T. Lehnert and M. Gijs 7: Using lab-on-a-chip technologies to understand cellular mechanotransduction; D. Pirone and C. Chen 8: Analysis of apoptosis on chip; F. Wolbers, C. Haanen, H. Andersson, A. van den Berg and I. Vermes 9: On chip single cell cultivation systems; K. Yasuda 10: Human embryonic stem cells and microfluidics; V. Abhyankar and D. Beebe 11: Cellular and subcellular analysis on chip; H. Lu, K. Jensen 12: Microfluidic cell culture devices; Y. Sakai, E. Leclerc , and T. Fujii 13: Micromachined bioreactor for in vitro cell self-assembly and 3D tissue formation; K. Domansky, A. Sivaraman and L. Griffith

Klappentext

Dear reader, In the past few years we have observed an interesting mutual interest of two fields of research and development in each other. Life sciences area researchers discovered the opportunities offered my micro- and nanotechnology, while people from the microfluidics and BIOMEMS area discovered the application potential of these technologies in cell biology. Unfortunately, these two research communities share little in common: they read and publish in different scientific journals, have incompatible jargons, attend separate conferences, and have a different scientific approach and culture. This is most strikingly illustrated when you give a MEMS researcher some cells to experiment with, or hand over a couple of chips to a cell biologist. Or imagine explaining a microengineer different intracellular apoptotic pathway or a cell biologist about tensile stress in underetched LPCVD membranes. And yet, there is an enormous potential of combining the expertises available in these two fields. It is our goal to illustrate this potential with this book focusing on microfluidics technologies for cellomics , research on or with cells. In our view, the field is still too immature to compile a textbook for students, and this volume is rather meant to be a collection of first class papers of leaders in this emerging field. This volume will enable researchers from both communities to get a rapid state of the art overview, and also to get an impression what kind of possibilities this area offers. Micro- and nanotechnologists will get inspiration about applications, life science researchers about technological capabilities.